| Yazarlar |
Orhan Çorum
Kastamonu Üniversitesi, Türkiye |
|
Duygu Çorum
Kastamonu Üniversitesi, Türkiye |
|
Ayşe Er
Selçuk Üniversitesi, Türkiye |
Doç. Dr. Ertuğrul TERZİ
Kastamonu Üniversitesi, Türkiye |
|
Kamil Üney
Selçuk Üniversitesi, Türkiye |
| Özet |
| Plasma and muscle pharmacokinetics of danofloxacin were investigated after 10 mg/kg intravenous (IV, caudal vein) and intramuscular (IM, right epaxial muscles) administrations in 168 healthy brown trout (Salmo trutta fario) at 10°C–13°C. High-performance liquid chromatography was used to determine its plasma and muscle concentrations. Pharmacokinetic parameters were analysed with a non-compartmental model. After IV administration, elimination half-life (t 1/2ʎz ), area under the concentration–time curve (AUC 0–∞ ), mean residence time (MRT 0–∞ ), volume of distribution at steady state, total body clearance in plasma and AUC Muscle /AUC Plasma ratio were 22.22 h, 140.66 h*µg/mL, 23.15 h, 2.28 L/kg, 0.07 L/h/kg and 3.79, respectively. After IM administration, t 1/2ʎz , AUC 0–∞ , MRT 0–∞ , peak concentration (C max ), time to reach C max , bioavailability in plasma and AUC Muscle /AUC Plasma ratio were 28.28 h, 84.39 h*µg/mL, 37.31 h, 4.79 µg/mL, 1 h, 59.99% and 8.46, respectively. Danofloxacin exhibited long t 1/2ʎz and good bioavailability after IM administration. Therefore, 10 mg/kg IM administration of danofloxacin in brown trout can provide AUC 0–24 /MIC of > 125 and C max /MIC of > 10 to treat diseases caused by susceptible bacteria with ≤ 0.336 µg/mL MIC. |
| Anahtar Kelimeler |
| Danofloxacin,brown trout,bioavailability,tissue,pharmacokinetics |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Food Additives Contaminants: Part A |
| Dergi ISSN | 1944-0049 |
| Dergi Tarandığı Indeksler | SCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 11-2018 |
| Cilt No | 35 |
| Sayı | 12 |
| Sayfalar | 2340 / 2347 |
| Doi Numarası | 10.1080/19440049.2018.1530458 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/19440049.2018.1530458 |
| Atıf Sayıları | |
| WoS | 18 |
| SCOPUS | 19 |
| Google Scholar | 28 |
