Plasma and tissue disposition of danofloxacin in brown trout (Salmo trutta fario) after intravenous and intramuscular administrations
Yazarlar (5)
Prof. Dr. Orhan Corum Kastamonu Üniversitesi, Türkiye
Doç. Dr. Duygu Durna Corum Kastamonu Üniversitesi, Türkiye
Prof. Dr. Ayse Er Selçuk Üniversitesi, Türkiye
Doç. Dr. Ertuğrul TERZİ Kastamonu Üniversitesi, Türkiye
Prof. Dr. Kamil Uney Selçuk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Food Additives and Contaminants Part A Chemistry Analysis Control Exposure and Risk Assessment | ||
| Dergi ISSN | 1944-0049 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 11-2018 |
| Kabul Tarihi | 22-09-2018 | Yayınlanma Tarihi | 23-10-2018 |
| Cilt / Sayı / Sayfa | 35 / 12 / 2340–2347 | DOI | 10.1080/19440049.2018.1530458 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/19440049.2018.1530458 | ||
| UAK Araştırma Alanları |
Su Kalitesi ve Su Kirliliği
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| Özet |
| Plasma and muscle pharmacokinetics of danofloxacin were investigated after 10 mg/kg intravenous (IV, caudal vein) and intramuscular (IM, right epaxial muscles) administrations in 168 healthy brown trout (Salmo trutta fario) at 10°C–13°C. High-performance liquid chromatography was used to determine its plasma and muscle concentrations. Pharmacokinetic parameters were analysed with a non-compartmental model. After IV administration, elimination half-life (t1/2ʎz), area under the concentration–time curve (AUC0–∞), mean residence time (MRT0–∞), volume of distribution at steady state, total body clearance in plasma and AUCMuscle/AUCPlasma ratio were 22.22 h, 140.66 h*µg/mL, 23.15 h, 2.28 L/kg, 0.07 L/h/kg and 3.79, respectively. After IM administration, t1/2ʎz, AUC0–∞, MRT0–∞, peak concentration (Cmax), time to reach Cmax, bioavailability in plasma and AUCMuscle/AUCPlasma ratio were 28 … |
| Anahtar Kelimeler |
| bioavailability | brown trout | Danofloxacin | pharmacokinetics | tissue |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 21 |
| Scopus | 22 |
| Google Scholar | 22 |