Two Different Reading Of Hanafiyya In The Context Of Tahavi (Akmaluddin al-Babarti and Ibn Abi'l-Izz Examplification)
Yazarlar (1)
Doç. Dr. Mustafa AYKAÇ Kastamonu Üniversitesi, Türkiye
Makale Türü Açık Erişim Özgün Makale (Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale)
Dergi Adı HITIT UNIVERSITESI ILAHIYAT FAKULTESI DERGISI-JOURNAL OF DIVINITY FACULTY OF HITIT UNIVERSITY
Dergi Tarandığı Indeksler
Makale Dili Türkçe Basım Tarihi 01-2018
Cilt / Sayı / Sayfa 17 / 33 / 80–87 DOI 10.5555/20210167015
Makale Linki https://www.cabidigitallibrary.org/doi/full/10.5555/20210167015
UAK Araştırma Alanları
Özet
Gastric carcinoma is a type of cancer in humans and animals with high morbidity and mortality. Gossypin is a natural flavonoid group isolated from Hibiscus vitifolius. In this study, it was aimed to investigate the anti-proliferative and apoptotic effects of gossypin in Kato-III cells. Cells were cultured in standard culture conditions. Cell viability and the effective dose range (5-100 μg/ml) of gossypin were determined at 24, 48 and 72nd hours by MTT. Caspase-3, 9, and NF-kB gene expressions were determined by Real Time-PCR method. Apoptosis levels were determined by fluorescent staining method. Cisplatin was used as positive control group. It was determined that Gossypin decreased Kato-III cell proliferation depending on the dose and time. Gossypin was found to increase caspase-3 and caspase-9 levels while inhibiting NF-kB levels, and the results were similar to cisplatin. Fluorescent staining results ...
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