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| Dergi Adı | HITIT UNIVERSITESI ILAHIYAT FAKULTESI DERGISI-JOURNAL OF DIVINITY FACULTY OF HITIT UNIVERSITY | ||
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| Makale Dili | Türkçe | Basım Tarihi | 01-2018 |
| Cilt / Sayı / Sayfa | 17 / 33 / 80–87 | DOI | 10.5555/20210167015 |
| Makale Linki | https://www.cabidigitallibrary.org/doi/full/10.5555/20210167015 | ||
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| Özet |
| Gastric carcinoma is a type of cancer in humans and animals with high morbidity and mortality. Gossypin is a natural flavonoid group isolated from Hibiscus vitifolius. In this study, it was aimed to investigate the anti-proliferative and apoptotic effects of gossypin in Kato-III cells. Cells were cultured in standard culture conditions. Cell viability and the effective dose range (5-100 μg/ml) of gossypin were determined at 24, 48 and 72nd hours by MTT. Caspase-3, 9, and NF-kB gene expressions were determined by Real Time-PCR method. Apoptosis levels were determined by fluorescent staining method. Cisplatin was used as positive control group. It was determined that Gossypin decreased Kato-III cell proliferation depending on the dose and time. Gossypin was found to increase caspase-3 and caspase-9 levels while inhibiting NF-kB levels, and the results were similar to cisplatin. Fluorescent staining results ... |
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| Google Scholar | 5 |