Bir Hemodiyaliz Hastasında Üç Kapak Tutulumu Olan Endokardit Vakası
Yazarlar (1)
Prof. Dr. Abdulkadir YILDIZ Kastamonu Üniversitesi, Türkiye
| Makale Türü |
Diğer (Teknik, not, yorum, vaka takdimi, editöre mektup, özet, kitap krıtiği,
araştırma notu, bilirkişi raporu ve benzeri)
(Diğer hakemli uluslararası dergilerde yayınlanan teknik not,
editöre mektup, tartışma, vaka takdimi ve özet türünden makale)
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| Dergi Adı | International Journal of Basic and Clinical Medicine | ||
| Dergi Tarandığı Indeksler | |||
| Makale Dili | Türkçe | Basım Tarihi | 04-2015 |
| Cilt / Sayı / Sayfa | 1 / 2 / 80–87 | DOI | 10.5555/20210167015 |
| Makale Linki | https://www.cabidigitallibrary.org/doi/full/10.5555/20210167015 | ||
| UAK Araştırma Alanları |
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| Özet |
| Gastric carcinoma is a type of cancer in humans and animals with high morbidity and mortality. Gossypin is a natural flavonoid group isolated from Hibiscus vitifolius. In this study, it was aimed to investigate the anti-proliferative and apoptotic effects of gossypin in Kato-III cells. Cells were cultured in standard culture conditions. Cell viability and the effective dose range (5-100 μg/ml) of gossypin were determined at 24, 48 and 72nd hours by MTT. Caspase-3, 9, and NF-kB gene expressions were determined by Real Time-PCR method. Apoptosis levels were determined by fluorescent staining method. Cisplatin was used as positive control group. It was determined that Gossypin decreased Kato-III cell proliferation depending on the dose and time. Gossypin was found to increase caspase-3 and caspase-9 levels while inhibiting NF-kB levels, and the results were similar to cisplatin. Fluorescent staining results ... |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
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