In vitro studies to investigate the potential neuroprotective and neurotransmitter modulation effects of a standardized Ginkgo biloba extract associated with phosphatidylserine
Yazarlar (14)
Doç. Dr. Mehtap Kara Istanbul Üniversitesi, Türkiye
Gozde Hasbal-Celikok
Istanbul Üniversitesi, Türkiye
Istanbul Üniversitesi, Türkiye
Pilar Gómez-Serranillos Universidad Complutense De Madrid, Facultad De Farmacia, İspanya
Marta Sánchez Gómez-Serranillos Universidad Complutense De Madrid, Facultad De Farmacia, İspanya
Claudia Owsianik
Universidad Complutense De Madrid, Facultad De Farmacia, İspanya
Universidad Complutense De Madrid, Facultad De Farmacia, İspanya
Tugba Yilmaz-Ozden
Istanbul Üniversitesi, Türkiye
Istanbul Üniversitesi, Türkiye
Doç. Dr. Ezgi Öztas Istanbul Üniversitesi, Türkiye
Nazli Arda
Istanbul Üniversitesi, Türkiye
Istanbul Üniversitesi, Türkiye
Merve Tunc
Istanbul Üniversitesi, Türkiye
Istanbul Üniversitesi, Türkiye
Doç. Dr. Çiğdem SEVİM Kastamonu Üniversitesi, Türkiye
Giovanna Petrangolini
Indena S.P.A., İtalya
Indena S.P.A., İtalya
Fazle Rabbani
Lady Reading Hospital, Pakistan
Lady Reading Hospital, Pakistan
Ikram Ujjan Liaquat University of Medical & Health Sciences, Pakistan
Amjad Khan Liaquat University of Medical & Health Sciences, Pakistan
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Frontiers in Nutrition (Q1) | ||
| Dergi ISSN | 2296-861X Dergi Bilgileri (2026) | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2026 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 18-02-2026 |
| Cilt / Sayı / Sayfa | 13 / 1 / – | DOI | 10.3389/fnut.2026.1764334 |
| Makale Linki | https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1764334/full | ||
| UAK Araştırma Alanları |
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| Özet |
| Cognitive impairment and mood disturbances are increasingly linked to underlying mechanisms such as oxidative stress, neurotransmitter dysregulation, and reduced neurotrophic support. As conventional pharmacological treatments often provide limited efficacy or are associated with tolerability concerns, there is growing scientific interest in botanical supporting strategies that may modulate the above pathways and provide complementary support for cognitive function and emotional well-being. This study aimed to investigate the mechanistic basis of a botanical association consisting of a standardized Ginkgo biloba extract (GBE) from leaves and phosphatidylserine (PS) (combined referred as GBP) (Virtiva™ Plus), focusing on its potential effects on neurotransmitter-related enzymes and receptors, neuroprotection under oxidative stress, neurotrophic signaling, and antioxidant capacity. GBP was characterized analytically and evaluated in a series of validated in vitro assays using human SH-SY5Y neuroblastoma cells and multiple cell-free antioxidant systems. Neurotransmitter effect assays demonstrated that GBP inhibited acetylcholinesterase (AChE) and monoamine oxidase-A (MAO-A) in a concentration-dependent manner, suggesting selective modulation of cholinergic and monoaminergic pathways relevant to cognition and mood regulation. Enzyme modulation observed at micromolar concentrations supports mechanistic plausibility of G. biloba constituents in neurochemical pathways rather than direct modeling of physiological exposure. In SH-SY5Y cells exposed to hydrogen peroxide (H2O2), GBP improved cell viability, confirming no … |
| Anahtar Kelimeler |
| BDNF | cognition | emotional well-being | Ginkgo biloba | neurotransmitter modulation | nutraceuticals | oxidative stress | phosphatidylserine |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 1 |
| Google Scholar | 1 |