COMT rs4680 and DRD2 rs6275 variants and their association with YMRS scores in children with early-onset bipolar disorder
Yazarlar (10)
M Cengiz
G Karacetin
Doç. Dr. Murat TOPAL Kastamonu Üniversitesi, Türkiye
M Elagoz Yuksel
T Eseroglu
GB Akdeniz
Türkay Demir
M Erkiran
A Dirican
B Bayoglu
Kastamonu Üniversitesi
Kastamonu Üniversitesi
| Makale Türü | Özgün Makale (Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale) | ||
| Dergi Adı | The European Journal of Psychiatry | ||
| Makale Dili | – | Basım Tarihi | 01-2023 |
| Cilt / Sayı / Sayfa | 37 / 1 / 8–14 | DOI | – |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S0213616322000581 | ||
| UAK Araştırma Alanları |
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| Özet |
| Background and objectivesBipolar disorder (BD) is a clinical status with at least one manic, hypomanic or mixed attacks. Genetic factors take part significantly in early-onset BD (EOBD). Dopamine receptors (DRD) act in neurological mechanisms like motivation, learning, memory, and, control of neuroendocrine signaling. DRD2 receptor has been reported to influence the stability of DRD2 transcript. Catechol-O-Methyl transferase (COMT) inactivates catecholamines and Val158Met variation on COMT has effects on COMT activity. This study aims to explore DRD2 and COMT variants in the clinical development of EOBD.MethodsIn this case-control study, 102 EOBD patients and 168 healthy control subjects were used. DRD2 rs6275 and COMT Val158Met variations were detected by real-time polymerase chain reaction (RT-PCR). Young Mania Rating Scale (YMRS) was utilized to determine the EOBD severity.Results … |
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BM Sürdürülebilir Kalkınma Amaçları
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| Google Scholar | 1 |