BDNF Val66Met polymorphism is associated with negative symptoms in early-onset schizophrenia spectrum and other psychotic disorders
Yazarlar (13)
Gül Karaçetin
Burcu Bayoglu
T Eseroglu Soylemez
Doç. Dr. Murat TOPAL Kastamonu Üniversitesi, Türkiye
E Bulanik Koc
Mehmet Tekden
Cagatay Ermis
Türkay Demir
M Elagoz Yuksel
Eyüp Sabri Ercan
M Erkiran
SB Aksoyer Sezgin
M Cengiz
Kastamonu Üniversitesi
Kastamonu Üniversitesi
| Makale Türü | Özgün Makale (Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale) | ||
| Dergi Adı | The European Journal of Psychiatry | ||
| Makale Dili | – | Basım Tarihi | 01-2022 |
| Cilt / Sayı / Sayfa | 36 / 1 / 26–34 | DOI | – |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S0213616321000252 | ||
| UAK Araştırma Alanları |
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| Özet |
| Background and ObjectivesTo investigate the clinical characteristics of adolescents with early-onset full psychotic disorders either with Brain-derived neurotrophic factor (BDNF) Val66Met (rs6265) or DRD2/ANKK1 Taq1A (rs1800497) polymorphisms.Method101 cases with early-onset schizophrenia (EOS) or other psychotic spectrum disorders (SSD) and 150 healthy controls were included in the current study. Using the Positive and Negative Symptom Scale (PANSS), patient subgroups were compared for their psychotic symptoms, age-onset, duration of untreated illness, and family history of psychiatric disorders. The real-time polymerase chain reaction (RT-PCR) was implemented for genotyping procedures.ResultsStudy groups and patient subgroups were similar regarding their sociodemographic characteristics (16.4 ± 2.6 years, 62.2% male for all participants). Results did not reveal any difference between … |
| Anahtar Kelimeler |
