| Yazarlar |
Sermin Algül
Yüzüncü Yıl Üniversitesi, Türkiye |
|
Yusuf Özkan
Türkiye |
Prof. Dr. Oğuz ÖZÇELİK
Fırat Üniversitesi, Türkiye |
| Özet |
| The aim of this study was to compare the levels of nesfatin-1 in healthy subjects with those in prediabetic and diabetic patients who have different glucose tolerance levels. Overall, 100 subjects were divided into 5 groups healthy control (C), impaired fasting glycemia (IFG), impaired glucose tolerance (IGT), metabolic syndrome (MS) and type 2 diabetes mellitus, (Type 2 DM). Glycated hemoglobin (HbA1c) assessed the glycemic control. Homeostasis model assessment of insulin resistance (HOMA-IR) was determined using computer analyses. Nesfatin-1 levels were measured using ELISA method. IFG and IGT (prediabetic groups) from MS and Type 2 DM (diabetic groups) differed significantly in HOMA-IR. The nesfatin-1 levels were lower, although not statistically significant, in IFG (0.937±0.03 ng/ml, p=0.07) and IGT (1.039±0.06 ng/ml, p=0.5) groups compared to healthy subjects (1.094±0.07 ng/ml). However, the nesfatin-1 levels were lower in patients with Type 2 DM (0.867±0.02 ng/ml, p=0.007) and MS (0.885±0.01 ng/ml, p=0.01) compared to healthy subjects. Nesfatin-1 levels were significantly lower in diabetic patients compared to healthy subjects. This study supports the role of insulin resistance in decreased nesfatin-1 levels in patients with Type 2 DM and MS. |
| Anahtar Kelimeler |
| Impaired glucose regulation | Insulin | Nesfatin-1 | Type 2 diabetes mellitus |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Physiological Research |
| Dergi ISSN | 1802-9973 |
| Dergi Tarandığı Indeksler | SCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2016 |
| Cilt No | 65 |
| Sayı | 6 |
| Sayfalar | 979 / 985 |
| Doi Numarası | 10.33549/physiolres.933186 |
| Atıf Sayıları | |
| SCOPUS | 41 |
| Google Scholar | 75 |
