| Yazarlar |
Sermin Algül
Van Yüzüncü Yıl Üniversitesi, Türkiye |
Prof. Dr. Oğuz ÖZÇELİK
Kastamonu Üniversitesi, Türkiye |
|
Gökhan Oto
Türkiye |
|
Mücahit Sarikaya
Türkiye |
|
Rezzan Temelli Göçeroğlu
|
|
Nuri Mert Embiyaoğlu
Türkiye |
|
Fatma Caf
Türkiye |
|
Salih Öner
Türkiye |
|
A Li Gevher. Akcan
|
| Özet |
| OBJECTIVE: We evaluated the efficacy of curcumin administration on blood glucose levels and its relationship with nesfatin-1 levels in blood brain and adipose tissue of streptozotocin-induced diabetic rats. MATERIALS AND METHODS: A total of 28 male rats were divided into four groups: control group, type 2 diabetes mellitus (DM) group, control plus curcumin group and type 2DM plus curcumin group. After fifteen days, blood samples were collected from sacrificed rats. Nesftain-1 levels were analysed from blood, brain, and fat tissues of rats in all groups. RESULTS: Nesfatin-1 level was found to be significantly lower in blood, brain and fat tissues of type 2 DM rats compared to the control group. A significant decrease in fasting blood glucose levels was observed in the curcumin administration group compared to type 2 DM group. Improvement of fasting blood glucose level was accompanied by improvement of nesfatin-1 levels in blood, brain, and fat tissues. CONCLUSIONS: As expected, curcumin administration caused significant improvement in fasting blood glucose levels. However, for the first time, we found marked improvements in nesfatin-1 levels in blood, brain, and fat tissues of type 2 DM rats. Thus, considering the crucial role of nesfatin-1 in regulation of glucose metabolism, it is logical to expect an interactive relationship between curcumin and nesfatin-1. |
| Anahtar Kelimeler |
| Curcumin | Diabetes | Nesfatin-1 | Rat | Streptozotocin |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Eur Rev Med Pharmacol Sci |
| Dergi ISSN | 2284-0729 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2021 |
| Cilt No | 25 |
| Sayı | 3 |
| Sayfalar | 1616 / 1621 |
| Doi Numarası | 10.26355/eurrev_202102_24872 |
| Makale Linki | https://www.europeanreview.org/wp/wp-content/uploads/1616-1621.pdf |
| Atıf Sayıları | |
| WoS | 6 |
| SCOPUS | 6 |
| Google Scholar | 7 |
