| Yazarlar |
Prof. Dr. Oğuz ÖZÇELİK
Kastamonu Üniversitesi, Türkiye |
H. Dogan
Firat Üniversitesi, Turkey |
|
H. Celik
Firat Üniversitesi, Turkey |
|
A. Ayar
Firat Üniversitesi, Turkey |
|
S. Serhatlioglu
Firat Üniversitesi, Turkey |
|
H. Kelestimur
Firat Üniversitesi, Turkey |
| Özet |
| We investigated the effects of different weight loss protocols on leptin levels in obese females with the aim of addressing the leptin resistance which has been found to be an aggravating factor in obesity. Twenty-four obese females enrolled to one of three 12-week weight loss protocols: orlistat-induced weight loss (OWL, n=8), exercise-induced weight loss (EWL, n=8) and orlistat plus exercise-induced weight loss (OEWL, n=8). Serum leptin levels were measured in duplicate by radioimmunoassay. There were significant reductions (P<0.01) in body weight and fat mass after the 12 week period in all groups: -11.4±0.5 kg and -9.8±0.5 kg (OEWL), -8.3±0.8 kg and -5.7±0.9 kg (OWL), -8.9±1.2 kg and -7.4±1.2 kg (EWL), respectively. Serum leptin levels were also decreased markedly in all groups: -59.2 % (OEWLI), -37.8 % (OWL) and -48.6 % (EWL) (P<0.01 all). In addition, there were marked decreases in leptin levels for each kilogram of fat mass after the 12 week period: -48.2±7.2 % (OEWL), -27.8±4.8 % (OWL) and -39.3±4.3 % (EWL) (P<0.01 all). Decreases in serum leptin levels expressed per kilogram of fat mass were significantly higher in the OEWL group compared to the OWL group (P=0.03). Consequently, an exercise training program in adjunct to pharmacotherapy provides higher weight reduction and fat mass loss in obesity treatment. It also seems to have further beneficial effects on leptin resistance, as indicated by decreases in leptin levels expressed per kilogram of fat mass. © 2005 Institute of Physiology, Academy of Sciences of the Czech Republic. |
| Anahtar Kelimeler |
| Exercise | Leptin | Obesity | Pharmacotherapy | Weight loss |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Physiol. Res |
| Dergi ISSN | 0862-8408 |
| Dergi Tarandığı Indeksler | SSCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2005 |
| Cilt No | 54 |
| Sayı | 3 |
| Sayfalar | 271 / 277 |
