| Yazarlar |
Doç. Dr. Emrah Hicazi AKSU
Atatürk Üniversitesi, Türkiye |
Fatih Mehmet Kandemir
Atatürk Üniversitesi, Türkiye |
|
Serkan Yıldırım
Atatürk Üniversitesi, Türkiye |
|
Sefa Küçükler
Atatürk Üniversitesi, Türkiye |
|
Muhammed Yaşar Dörtbudak
Harran Üniversitesi, Türkiye |
|
Cüneyt Çağlayan
Bingöl Üniversitesi, Türkiye |
|
Fulya Benzer
Munzur Üniversitesi, Türkiye |
| Özet |
| This study aimed to investigate the effect of curcumin (CUR) on doxorubicin (DOX)-induced testicular damage in male rats. Thirty-five adult male Wistar rats were used. Control group was received saline for 7 days. CUR group received CUR for 7 days. DOX group received single dose DOX on the 5th day. DOX+ CUR-100 group received 100 mg/kg/day CUR for 7 days and DOX injection on the 5th day. DOX + CUR-200 group received 200 mg/kg/day CUR for 7 days and DOX injection on the 5th day. DOX treatment decreased in sperm motility rate, live sperm percentages, cellular antioxidants, and increased malondialdehyde (MDA) levels, necrosis, degenerations, and slimming in seminiferous tubules, and DNA damages in testes by inducing oxidative stress. CUR treatment mitigated significantly these side effects when compared with DOX group in a dose-dependent manner. In conclusion, CUR treatment can be used in the mitigation of DOX-induced testicular toxicity. |
| Anahtar Kelimeler |
| curcumin | DNA damage | doxorubicin | oxidative stress | testicular toxicity |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY |
| Dergi ISSN | 1095-6670 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2019 |
| Cilt No | 33 |
| Sayı | 10 |
| Doi Numarası | 10.1002/jbt.22384 |
| Makale Linki | https://onlinelibrary.wiley.com/doi/abs/10.1002/jbt.22384 |
| Atıf Sayıları | |
| WoS | 35 |
| SCOPUS | 35 |
