| Yazarlar |
Doç. Dr. Emrah Hicazi AKSU
Atatürk Üniversitesi, Türkiye |
Fatih Mehmet Kandemir
Atatürk Üniversitesi, Türkiye |
|
Serdar Altun
Atatürk Üniversitesi, Türkiye |
|
Sefa Küçükler
|
|
Selim Çomaklı
Atatürk Üniversitesi, Türkiye |
|
Ali Doğan Ömür
Atatürk Üniversitesi, Türkiye |
| Özet |
| Cisplatin (CP) treatment causes the damage in male reproductive system. Carvacrol (CARV) is an antioxidant that is naturally found in some plants. We aimed to investigate the effect of CARV on CP-induced reproductive toxicity in male rats. Eighteen adult male Sprague–Dawley rats were used. The control group (n = 6) was treated orally with physiological saline (PS) daily for 14 days and a single intraperitoneal (IP) PS injection on day 10. The CP group (n = 6) was administered with daily oral PS for 14 days and a single IP injection of 10 mg/kg CP on day 10. The CARV + CP group (n = 6) was treated with daily 75 mg/kg oral CARV for 14 days and a single IP injection of 10 mg/kg CP on day 10. CP treatment caused the damage on some spermatological parameters (motility, live sperm rate, and abnormal sperm rate), increased the oxidative stress, and induced testicular degeneration and apoptosis. However, CARV treatment mitigates CP-induced reproductive toxicity. |
| Anahtar Kelimeler |
| Apoptosis | Carvacrol | Cisplatin | Oxidative Stress | Spermiotoxicity |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY |
| Dergi ISSN | 1095-6670 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2016 |
| Cilt No | 30 |
| Sayı | 10 |
| Sayfalar | 513 / 520 |
| Doi Numarası | 10.1002/jbt.21816 |
| Makale Linki | http://doi.wiley.com/10.1002/jbt.21816 |
| Atıf Sayıları | |
| WoS | 32 |
| SCOPUS | 38 |
