Investigation on the effects of pomiferin from Maclura pomifera on indomethacin-induced gastric ulcer: An experimental study in rats
Yazarlar (8)
İlyas Bozkurt Ardahan Üniversitesi, Türkiye
Prof. Dr. Esra Dilek Erzincan Binali Yıldırım Üniversitesi, Türkiye
Doç. Dr. Hüseyin Serkan Erol Atatürk Üniversitesi, Türkiye
Prof. Dr. Ahmet Çakır Kilis 7 Aralık Üniversitesi, Türkiye
Prof. Dr. Ergin Hamzaoğlu Gazi Üniversitesi, Türkiye
Prof. Dr. Murat Koç Ankara Yıldırım Beyazıt Üniversitesi, Türkiye
Osman Nuri Keleş Atatürk Üniversitesi, Türkiye
Prof. Dr. Mesut Bünyami Halıcı Atatürk Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | MEDICINAL CHEMISTRY RESEARCH | ||
| Dergi ISSN | 1054-2523 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2017 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 12-05-2017 |
| Cilt / Sayı / Sayfa | 26 / 9 / 2048–2056 | DOI | 10.1007/s00044-017-1913-y |
| Makale Linki | http://link.springer.com/10.1007/s00044-017-1913-y | ||
| Özet |
| Previously, water extract of Maclura pomifera plant has been found effective on gastric damage. In this study, pomiferin product was purified from this plant by thin-layer chromatography method and its structure was elucidated by nuclear magnetic resonance methods. Its antiulcer effect was investigated on indomethacin-induced gastric damage in rats. For this study, a total of 36 Sprague Dawley female rats were divided into six groups such as healthy, control, reference, and three treatment groups (n = 6 each). Ranitidine (Ulcuran® 25 mg/ml vial) was used as reference. Biochemically, lipid peroxidation, and glutathione levels as well as superoxide dismutase, catalase, myeloperoxidase, and cyclooxygenase isoenzymes activities were measured in stomach tissues. Comparing with healthy group, ulcerative area was observed in control group (only administered to indomethacin group). However, Ulcerative area in stomach tissues of rats administered of all doses of pomiferin and ranitidine showed significant decrease (p < 0.05). Also, there were significant changes at the antioxidant levels (lipid peroxidation, glutathione, superoxide dismutase, and catalase) and some important enzyme activities (myeloperoxidase, cyclooxygenase isoenzymes). We found that pomiferin was effective on gastric damage induced by indomethacin. This effect was thought to be caused by positive changes in the antioxidant system. |
| Anahtar Kelimeler |
| Antioxidant system | Maclura pomifera | Pomiferin | Ulcer | İndomethacin |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |